Premier League Matchday 35 Odds, Picks & Predictions (2025)
Liverpool secured the English Premier League (EPL) title last weekend, improving to 25-7-2 (82 points) with a 5-1 blowout win against visiting Tottenham. Although the championship is finalized, there's still plenty of thrilling action on the horizon, as teams continue jockeying for positioning in the table.
Below, I'll dive into three matches from a sports betting perspective and let you know where I'm laying my money on the English pitch this weekend.
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Premier League Matchday 35 Preview & Best Bets (2025)
(Odds courtesy of DraftKings Sportsbook)
Brentford (-140) vs. Manchester United (+360), DRAW (+310) | O/U 2.5 (-145/+115)
Let's pick it up on Sunday morning, where we have an intriguing bottom-half clash between Brentford and Manchester United. The Bees are in 11th at 14-7-13 (49 points), while the visiting Red Devils find themselves in 14th place at 10-9-15 (39 points). Kickoff is scheduled for 9:00 a.m. ET from Gtech Community Stadium in Brentford.
Manchester United has been in horrific form in the Premier League recently, posting a 0-2-3 record across five April matches. The offense has been tough to come by for Ruben Amorim's men, as they've been out-scored 6-2 during the five-match stretch. That includes getting shut out in three of those five contests. Their offense is now 16th in scoring (39 goals) and 12th in expected goals (xG) with a mark of 45.7.
Brentford's defense is a bit suspect, but they make up for it by boasting a very dangerous attack. The Bees are seventh in scoring (58 goals), averaging 1.71 goals per match. They're in the midst of a two-game winning streak, where they've netted six goals during the 180 minutes of play. I like Brentford to outpace the visitors in this one, and I think we could see them earn a multi-goal victory. I'll lay a goal with the Bees in front of their home fans.
Bet: Brentford -1 (+125)
Chelsea (+115) vs. Liverpool (+220), DRAW (+275) | O/U 3.5 (+135/-170)
The marquee match on Sunday comes in the capital city, as Chelsea and Liverpool square off in a rivalry showdown. The Reds won their first title since 2019-20 last weekend, and the Blues are competing for a top-four spot, sitting in fifth at 17-9-8 (60 points). Kickoff is set for 11:30 a.m. ET from Stamford Bridge in London.
Chelsea's offense was on an absolute tear to start the campaign, but it's been their defense that's dominated down the stretch, putting them in contention for a coveted top-four spot. The Blues come into the matchday ranked third in goals conceded (40) and sixth in expected goals allowed (xGA) with a mark of 43.2. They're coming off a 1-0 clean sheet win over Everton, and they've now blanked five of their last eight Premier League opponents.
Meanwhile, Arne Slot's crew is firing on all cylinders this season, which is exemplified by their league-leading +48 goal differential. For context, Arsenal and Manchester City are the next-closest at +34 and +24, respectively. With that said, the Reds have simply been lights out defensively, ranking second in goals allowed (32) and first in xGA (28.9). Finally, it's worth noting that the under 3.0 goals is 9-1-2 in the last 12 head-to-head meetings between these clubs across all competitions. Give me the alternative under of 3.0 goals.
Bet: Alt Under 3.0 Goals (-110)
Crystal Palace (+125) vs. Nottingham Forest (+230), DRAW (+240) | O/U 2.5 (-105/-120)
The matchday wraps up on Monday with a fun mid-table contest between Crystal Palace and Nottingham Forest. The Tricky Trees have dropped out of the top four, and they enter the weekend in sixth place at 18-6-10 (60 points). The hosting Eagles are in 12th at 11-12-11 (45 points). The matchday finale gets underway at 3:00 p.m. ET from Selhurst Park in London.
I'll play the double chance in favor of Nottingham Forest on Monday, wagering they'll either win or draw on the road against Crystal Palace. This is a pivotal match for the Trees, as they try to stay in contention for a Champions League bid. Forest should be able to lean on its top-tier defense and at least manage a draw on the road, if not win outright.
Nottingham Forest's defense has been exceptional this year, ranking second in clean sheets (13), while posting a clean sheet percentage of 38.2%. Palace doesn't have much to offer offensively, as they're a modest 14th in scoring (43 goals) and 10th in xG (51.3). The hosts are also winless across their last four Premier League matches (0-2-2), and they have a win rate of just 32.4% (11-12-11) this season. I like Forest's chances to capture at least one point, so I don't mind laying the -155 vig in this high-leverage spot on a double chance bet.
Bet: Double Chance: Nottingham Forest to Win or Draw (-155)