3 Best NFL Bets for Week 2 (2025)
There are many unique and profitable betting systems that you can use to find wagers during this NFL season. I found three incredible NFL bets using some of the most profitable systems on the site. Check out our premium betting systems and picks below.
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Week 2’s Best NFL Betting System & Trends Picks
(Odds courtesy of DraftKings Sportsbook)
Plus Money Underdog Interceptions Unders
The “Plus Money Underdog Interceptions Unders” system has added a 20.9% return on investment (ROI) over the last year. It looks for players who are underdogs but have odds of +101 or lower to go under on their interception prop line. This system has achieved a 55% win rate and a profit of 10.26 units over its last 49 bets.
Michael Penix Jr. fits the bill. He didn’t throw an interception last week against the Buccaneers on 42 pass attempts. Dating back to last season, he has averaged 24.5 passing attempts per game. He nearly doubled that and didn’t throw an interception last week. In addition, 34 of those 42 passes were on target, and only five of his passes were considered poor passes.
Penix will battle a Vikings defense that earned a 40 grade in coverage in Week 1, per Pro Football Focus (PFF). Minnesota can stop the run, but the coverage is a bit shaky. Let’s back Penix to limit himself to zero interceptions on Sunday.
Pick: Michael Penix Jr. Under 0.5 Interceptions (+105)
Rushing Yards Unders vs Chiefs
Betting on unders for rushing yards in Chiefs games has been profitable lately. Over the last 74 bets in Chiefs games, players have hit the under for their rushing yards props 62% of the time. That’s a profit of more than nine units and an ROI of 12.7%.
You can choose any key player for this bet. But I’ll run with Kareem Hunt, who added only 16 rushing yards against the Chargers in Week 1 this season. He also finished with only nine rushing yards against the Eagles in last year’s Super Bowl.
Over his last two games, Hunt has a combined 25 rushing yards. He’s not going to be the lead back for the Chiefs. He’ll potentially be a goal-line back, but that’s fine since we’re taking the under on his rushing yards.
Pick: Kareem Hunt Under 22.5 Rushing Yards (-118)
Passing Touchdowns Overs 1.5 to 2 TDs (60%+ Hit Rate L5)
This final system looks for players to add over 1.5 or two passing touchdowns. The player must have hit this line in 50% of games during the season and has to have hit the over in three of his last five and six of his last 10 in the regular season. This system has earned a 15.3% ROI over its last 83 bets and has won 64% of the time.
Lamar Jackson is currently one of two upcoming bets for this system. Jackson has added at least two passing touchdowns in nine consecutive games and has odds of just -147 to do it again against the Cleveland Browns. The Browns played well against the Bengals last week, but the Ravens’ offense looks to be on a whole other level. Let’s back Jackson to earn at least two passing touchdowns in Sunday’s games.
Pick: Lamar Jackson Over 1.5 Passing Touchdowns (-147)